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122.Total Synthesis of Sinensilactam A
Wenbin Shao, Jun Huang, Kai Guo, Jianxian Gong*, and Zhen Yang*
The total synthesis of naturally occurring (±)-sinensilactam A was achieved in 18 steps. The key steps of this work are a rhodium-catalyzed [3 + 2] cycloaddition for construction of the two all-carbon vicinal quaternary centers and a convergent and tandem condensation of the in situ generated N-acyliminium intermediate with aldehyde 20. This enabled implementation of a unified strategy for stereoselective formation of the tetracyclic hemiaminal core of sinensilactam A in a later stage. The total syntheses of applanatumol F and C8-epi-applanatumol D are also achieved using this strategy.
Prof. Yang wins Asian Core Program Lectureship Award
Prof. Yang attended the 12th International Conference on Cutting-Edge Organic Chemistry in Aisa (ICCEOCA-12), and wins Asian Core Program Lectureship Award.
Mr. Zhang Pengpeng Wins Second Prize of 2017 ACS Shanghai Chapter Outstanding Graduate Student Research Award
Prof. Yang and Prof. Gong titled as Excellent Research Advisors.
Wenbin Shao and Yuanyuan Chang have successfully defended their dissertations
Wenbin Shao and Yuanyuan Chang have successfully defended their dissertations and shall be conferred the doctor’s degree. Congratulations!
Congratulation to Mr. Zhang for his work was published on JACS!
For more details, please see the paper online:
https://web.pkusz.edu.cn/yang/121/
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