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Congratulations to Prof. Yang on winning the first class prize of the Guangdong Science and Technology Award for 2014.
The Guangdong Science Innovation Conference was held by the Guangdong government in Shenzhen on February 27th . In the conference, the Guangdong Science and Technology Awards for 2014 were announced. Professor Yang, with his research in “the total synthesis of natural products with significant biological activities” won the first class prize of the Guangdong Science and Technology Award for 2014. After the award ceremony, Prof. Yang was interviewed by the Shenzhen TV.
Prof. Yang took photo with Dr. Gong after he received the certificate of award
After the ceremony, Prof. Yang was interviewed by the Shenzhen TV.
91.Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes
Shuang Li, Fuzhuo Li, Jianxian Gong*, and Zhen Yang*
The Pd(II)-catalyzed intramolecular carbonylative cyclization reaction of aryl alkenes and aryl alkenols is reported for the synthesis of structurally diverse chromanes. PdCl2(CH3CN)2 was used as the catalyst and CuCl2 as the oxidant under the balloon pressure of CO. The reaction is conducted under mild conditions, and chromane-type esters and lactones can be generated in a highly regio- and stereoselective manner.
Congratulations to Prof. Yang on winning the first class prize of the Shenzhen Natural Science Award for 2013.
The Shenzhen government announced the Shenzhen Scientific and Technical Awards for 2013 on 2014 Dec 18th. Professor Yang, with his research in “the total synthesis of natural products with significant biological activities” won the first class prize of the Shenzhen Natural Science Award. And this’s the only one in the first class, the other four projects won the second class prize.
Prof. Yang received the certificate of award on the ceremony
Before the ceremony, Prof. Yang was interviewed by the Shenzhen TV.
The selected achievements of the group in the project of “the total synthesis of natural products with significant biological activities”
90.Total Synthesis of Maoecrystal V
Wei-Bin Zhang, Dr. Guang Lin, Wen-Bin Shao, Dr. Jian-Xian Gong,* and Prof. Dr. Zhen Yang*
Maoecrystal V (1) is a novel diterpenoid, which was originally isolated from the leaves of the Chinese medicinal herb Isodon eriocalyx in 2004 by Sun et al.1 It has been found to be selectively cytotoxic towards HeLa cells, with an IC50 value of 20 ng mL−1. Significant research efforts have been devoted to the synthesis of maoecrystal V because of its intriguing biological properties, rarity in nature, and complex structural features. Herein, we describe our recent investigations, which have culminated in the total synthesis of (±)-maoecrystal V. The current strategy involved three key steps for the successful construction of the key tetrahydrofuran oxa-bridge skeleton, including a Wessely oxidative dearomatization, a novel intramolecular Diels–Alder reaction, and a RhII-catalyzed O[BOND]H insertion reaction.
