The helical peptide KLA (KLAKLAKKLAKLAK) is a well known inducer of cellular apoptosis, acting to disrupt the mitochondrial membrane. However, its weak cellular uptake impedes developing any further applications. Here, we have utilized a novel in-tether chiral center induced...
The 2017 New Year party was held in Shenzhen Jinbaihe Hotel in the evening of January 5, 2017. All the members in our school enjoyed the splendid audio-visual feast! Link: http://scbb.pkusz.edu.cn/index.php?=content&c=index&a=show&catid=862&id=1356
Li group published article on Theranostics about a study of siRNA delivery with PEGylated graphene oxide nanosheets for combined photothermal and genetherapy for pancreatic cancer. Since the successful exfoliation of graphene from graphite in 2004, graphene and graphene...
Recently, we developed methods to stabilize peptides into various secondary structures, including a-helix, type III turn and b-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic...
Recapitulation of well-defined α-helices could result in constrained peptide mimetics with preferable secondary structures and enhanced therapeutic properties for various purposes. Among the helix-stabilizing strategies, the nucleation strategies are able to maximize recognition specificity of the original sequence without...
A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is...
Prof. Fei Sun from Hong Kong University of Science and Technology visited our school and gave an interesting lecture titled “Synthetic Biology Approaches toward Protein-Based Materials”
Prof. Changmin Yu from South China University of Technology and Prof. Zhiqiang Yu from Southern Medical University visited our school and gave an interesting lecture about nano materials.
The facile chemical modification on the peptide cross-linking moiety is an important strategy to improve the physicochemical properties of a peptide. Herein, peptides were contrained into helical conformations via the synergistic effects of dual in-tether chiral centers. A pentapeptide...
In some cases, helical peptides stabilized by an i, i + 7 tether exhibit bettertargetbindingandcellularfunctionscomparedtotheiri, i+4 analogues. Herein, we carried out a systematic study of the effects of an in-tether chiral center on the i, i + 7 system....
Modification of the cross-linker of constrained peptides has recently received considerable attention. Here, we present a versatile approach to modify the cross-linking tether of chiral center-induced helical (CIH) peptides via S-alkylation reac-tion. The alkylation process displayed high conversion efficiency,...
As a novel semiconducting material, the inherent, direct, and appreciable band gap endows BP with preferable optical and electronic properties other than graphene and transition metal dichalcogenides. In addition, bio-related applications with equal importance also attract great attention thanks...
Way to go !!! We wish you the best in your future endeavours!
A chirality induced helicity method has been developed to modulate the peptide’s biophysical and biochemical properties. We report herein a novel approach for reversibly switching the conformation of short constraint α-helical peptides through alkylation of the in-tether thioether and...
Cytolytic peptides are an emerging class of promising cancer therapeutics shown to overcome drug resistance. They eliminate cancer cells via disruption of the phospholipid bilayer of cell membranes, a mechanism that differentiates it from traditional treatments. However, applications of...
