Latest posts

Li group published article on Synlett about a study of lipid–cell-penetrating-peptide conjugates as effective delivery systems

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is...

Li group published article on The Chemical Record about a review of Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation

Recently, we developed methods to stabilize peptides into various secondary structures, including a-helix, type III turn and b-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic...

The 2017 New Year Party

The 2017 New Year party was held in Shenzhen Jinbaihe Hotel in the evening of January 5, 2017. All the members in our school enjoyed the splendid audio-visual feast! Link: http://scbb.pkusz.edu.cn/index.php?=content&c=index&a=show&catid=862&id=1356  

Li group published article on Organic & Biomolecular Chemistry about a study of Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids

Cell penetration and nucleus translocation efficiency are important for the cellular activities of peptide therapeutics. For helical peptides stabilized by N-terminal crosslinked aspartic acid, correlations between their penetration efficiency/nucleus translocation and physicochemical properties were studied. An increase in hydrophobicity...

Li group published article on Bioconjugate Chemistry about a study of reversible and versatile on-tether modification of chiral center-induced helical peptides

Modification of the cross-linker of constrained peptides has recently received considerable attention. Here, we present a versatile approach to modify the cross-linking tether of chiral center-induced helical (CIH) peptides via S-alkylation reac-tion. The alkylation process displayed high conversion efficiency,...

Li group published article on Journal of Materials Chemistry B about a study of black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells

As a novel semiconducting material, the inherent, direct, and appreciable band gap endows BP with preferable optical and electronic properties other than graphene and transition metal dichalcogenides. In addition, bio-related applications with equal importance also attract great attention thanks...