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Li group published article on The Chemical Record about a review of Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation

Recently, we developed methods to stabilize peptides into various secondary structures, including a-helix, type III turn and b-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic...

The 2017 New Year Party

The 2017 New Year party was held in Shenzhen Jinbaihe Hotel in the evening of January 5, 2017. All the members in our school enjoyed the splendid audio-visual feast! Link: http://scbb.pkusz.edu.cn/index.php?=content&c=index&a=show&catid=862&id=1356  

Li group published article on Organic & Biomolecular Chemistry about a study of Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids

Cell penetration and nucleus translocation efficiency are important for the cellular activities of peptide therapeutics. For helical peptides stabilized by N-terminal crosslinked aspartic acid, correlations between their penetration efficiency/nucleus translocation and physicochemical properties were studied. An increase in hydrophobicity...

Li group published article on Organic & Biomolecular Chemistry about a study of Switching substitution groups on the in-tether chiral centre influences backbone peptides’ permeability and target binding affinity

Different substitution groups on the in-tether chiral centre of chirality-induced helical peptides (CIH peptides) showed distinguishable effects on the peptides’ cellular uptakes and binding affinities with the estrogen receptor α(ER-α). This study proves that in-tether chiral centres are a...

Li group published article on Bioorganic & Medicinal Chemistry about a study of An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides

Li group published article on Bioorganic & Medicinal Chemistry about a study of An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides. Thanks to their large binding interfaces, peptides are attractive ligands targeting protein-protein interactions compared...

Li group published article on Synlett about a study of lipid–cell-penetrating-peptide conjugates as effective delivery systems

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is...

Li group published article on Chembiochem about a study of effect of stapling architecture on physiochemical properties and cell permeability of stapled – helical peptides

Stapled peptides emerged as a new class of targeting molecules of high binding affinity and specificity for intracellular undruggable targets. Their ability to penetrate cell membranes were exceptionally intriguing to the field, yet elusively and controversially discussed. To understand...