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Li group published article on Bioconjugate Chemistry about a study of reversible and versatile on-tether modification of chiral center-induced helical peptides

Modification of the cross-linker of constrained peptides has recently received considerable attention. Here, we present a versatile approach to modify the cross-linking tether of chiral center-induced helical (CIH) peptides via S-alkylation reac-tion. The alkylation process displayed high conversion efficiency,...

Li group published article on Cell Chemical Biology about a study of Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus

Li group published article on Cell Chemical Biology about a study of  Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus  The increasing threats of antibiotic resistance urge the need for developing new strategies against bacterial...

Li group published article on Journal of Materials Chemistry B about a study of black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells

As a novel semiconducting material, the inherent, direct, and appreciable band gap endows BP with preferable optical and electronic properties other than graphene and transition metal dichalcogenides. In addition, bio-related applications with equal importance also attract great attention thanks...

Li group published article on Journal of Materials Chemistry B about a study of organosilicon modification enhanced the stability of black phosphorus nanosheets at ambient conditions

Thanks to its tunable direct-bandgap, high charge-carrier mobility and unique in-plane anisotropic structure, black phosphorus (BP) has become a rising star of post-graphene two-dimensional (2D) nanomaterials. However, BP is unstable in the ambient conditions which largely limits its application....

Li group published article on RSC Advances about a study of Lanthanide chelate-encapsulated polystyrene nanoparticles for rapid and quantitative immunochromatographic assay of procalcitonin

Lanthanide chelate-encapsulated polystyrene nanoparticles for rapid and quantitative immunochromatographic assay of procalcitonin Procalcitonin (PCT) is a potentially specific early marker of bloodstream infection and sepsis. In this work, we report, for the first time, the development of a fluorescence-based...

Li group published article on Bioconjugate Chemistry about a study of Investigation of Cellular Uptakes of the In-Tether Chiral-CenterInduced Helical Pentapeptides

Li group published article on Bioconjugate Chemistry about a study of Investigation of Cellular Uptakes of the In-Tether Chiral-CenterInduced Helical Pentapeptides We recently reported that a precisely positioned in-tether chiral center can modulate backbone peptides’ secondary structures, which provides an...