Home > Research Progress > Li group published article on Organic & Biomolecular Chemistry about a study of An in-tether sulfilimine chiral center induces ß turn conformation in short peptides

Li group published article on Organic & Biomolecular Chemistry about a study of An in-tether sulfilimine chiral center induces ß turn conformation in short peptides

image file: c6ob01805j-f1.tif

A sulfilimine chiral center in the tether at i, i + 3 positions of short peptides was systematically studied to elucidate the chirality-driven conformational changes. A rare and unexpected type III β-turn structure was induced in short peptides by an in-tether chiral center, supported by circular dichroism spectroscopy, NMR and X-ray crystallography.

Linking:  http://pubs.rsc.org/-/content/articlehtml/2016/ob/c6ob01805j