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2011 — present

132. Wan, C.; Yang, D.; Guo, X.; Zhang, T.; Ruan, Z.; Dai, C.; Xing, Y.; Yin, F.; Wang, R.; Li, Z. β-Carbonyl Sulfonium Enables Cysteine-Specific Bioconjugation for Activity-Based Protein Profiling in Live Cells. Chem. Commun. 2024, 10.1039.D4CC00295D. https://doi.org/10.1039/D4CC00295D.

131. Wan, C.; Yang, D.; Song, C.; Liang, M.; An, Y.; Lian, C.; Dai, C.; Ye, Y.; Yin, F.; Wang, R.; Li, Z. A Pyridinium-Based Strategy for Lysine-Selective Protein Modification and Chemoproteomic Profiling in Live Cells. Chem. Sci. 2024, 10.1039.D3SC05766F. https://doi.org/10.1039/D3SC05766F.

130. Wan, C.#; Zhang, Y.#; Wang, J.; Xing, Y.; Yang, D.; Luo, Q.; Liu, J.; Ye, Y.; Liu, Z.; Yin, F.; Wang, R.; Li, Z. Traceless Peptide and Protein Modification via Rational Tuning of Pyridiniums. J. Am. Chem. Soc. 2024, 146 (4), 2624–2633. https://doi.org/10.1021/jacs.3c11864.


129.  Qinhong Luo,‡ Yaqi Wang,‡ Zhanfeng Hou,‡ Huiting Liang, Licheng Tu, Yun Xing, Chuan Wan, Jianbo Liu, Rui Wang, Lizhi Zhu, Wei Han, Jianlong Wu,* Fei Lu,* Feng Yin,* and Zigang Li*, “Covalent PROTAC Design Method Based on a Sulfonyl Pyridone Probe”, Chem. Commun. 2024, https://doi.org/10.1039/D3CC05127G

128. Zhan, M.; Xing, Y.; Li, Z.; Yin, F. “A GSH-Resistant FK228 Analogue Containing a Stable Disulfide Bond”, Bioorganic Chemistry 2024, https://doi.org/10.1016/j.bioorg.2024.107119

127. Wanjin Zhong, Chuan Wan, Ziyuan Zhou, Chuan Dai, Yichi Zhang, Fei Lu*, Feng Yin*, and Zigang Li*, “4-Iodine N-Methylpyridinium-Mediated Peptide Synthesis”, Org. Lett., 2023, https://pubs.acs.org/doi/10.1021/acs.orglett.3c03539

126. Hailing Chen, Meimiao Zhan, Yaping Zhang, Jianbo Liu, Rui Wang, Yuhao An, Zhanxia Gao, Leying Jiang, Yun Xing, Yibin Kang*, Zigang Li*, and Feng Yin*, “Intracellular Delivery of Stabilized Peptide Blocking MTDH-SND1 Interaction for Breast Cancer Suppression”, JACS Au, 2023, https://pubs.acs.org/doi/10.1021/jacsau.3c00573

125. Qinhong Luo#, Yue Ma#, Huiting Liang#, Yuan Feng, Na Liu, Chenshan Lian, Lizhi Zhu, Yuxin Ye, Zhihong Liu, Zhanfeng Hou, Sijin Chen, Yaqi Wang, Chuan Dai, Chunli Song, Min Zhang, Zhipeng He, Yun Xing, Wanjin Zhong, Shuiming Li, Jianlong Wu,* Fei Lu,* Feng Yin,* and Zigang Li*, “Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region”, J. Med. Chem., 2023, https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01549

124. Chuan Dai#, Xiaochun Guo#, Zhuoheng Pan#, Chuan Wan, Dongyan Yang, Yongli Li, Chenshan Lian, Yuhao An, Tuanjie Zhang, Fadeng Yang, Lizhi Zhu*, Feng Yin*, Rui Wang*, Zigang Li*. “Pyridinium-Based Strategy for a Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome”, Anal. Chem., 2023, https://pubs.acs.org/doi/full/10.1021/acs.analchem.3c04279

123. Chunli Song#, Zijun Jiao#, Zhanfeng Hou#, Rui Wang, Chenshan Lian, Yun Xing, Qinhong Luo, Yuhao An, Fenfang Yang, Yuechen Wang, Xinrui Sha, Zhijun Ruan, Yuxin Ye, Zhihong Liu, Zigang Li*, and Feng Yin*, “Selective Protein of Interest Degradation through the Split-and-Mix Liposome Proteolysis Targeting Chimera Approach”, J. Am. Chem. Soc., 2023, https://doi.org/10.1021/jacs.3c05948

122. Xiaochun Guo, Yuena Wang, Yuhao An, Zhihong Liu, Jianbo Liu, Jiaxin Chen, Mei-miao Zhan, Mingcha Liang, Zhanfeng Hou, Chuan Wan, Feng Yin*, Rui Wang*, Zigang Li*, “Development of Lysine Crotonyl-mimic Probe to Covalently Identify H3K27Cr Interacting Proteins”, Chemistry – A European Journal, 2023, https://doi.org/10.1002/chem.202301624

121. Zhanfeng Hou, Chuan Wan, Yun Xing, Xiaochun Guo, Yaping Zhang, Rui Wang*, Feng Yin*, and Zigang Li*, “Bioorthogonal Fluoride-Responsive Azide and Alkynyl Pyridinium Click Cycloaddition in Vitro and in Live Cells”, Org. Lett., 2023, https://doi.org/10.1021/acs.orglett.3c01403

Figure 1

120. Fenfang Yang#, Qinhong Luo#, Yuechen Wang, Huiting Liang, Yaqi Wang, Zhanfeng Hou, Chuan Wan, Yuena Wang, Zhihong Liu, Yuxin Ye, Lizhi Zhu, Jianlong Wu, Feng Yin*, and Zigang Li*, “Targeted Biomolecule Regulation Platform: A Split-and-Mix PROTAC Approach”, J. Am. Chem. Soc., 2023, https://doi.org/10.1021/jacs.2c12824

Figure 1

119. Chuan Wan‡, Zhanfeng Hou‡, Dongyan Yang‡, Ziyuan Zhou, Hongkun Xu, Yuena Wang, Chuan Dai, Mingchan Liang, Jun Meng, Jiean Chen, Feng Yin*, Rui Wang*, Zigang Li*, “The thiol-sulfoxonium ylide photo-click reaction for bioconjugation”, Chemical Science, 2023, https://doi.org/10.1039/D2SC05650J

Graphical abstract: The thiol-sulfoxonium ylide photo-click reaction for bioconjugation

118. Yaping Zhang, Hongkun Xu, Leying Jiang, Zhaodi Liu, Chenshan Lian, Xiaofeng Ding, Chuan Wan, Na Liu, Yuena Wang, Zhiqiang Yu, Lizhi Zhu*, Feng Yin*, Zigang Li*, “Sulfonium-Driven Neoantigen-Released DNA Nanodevice as a Precise Vaccine for Tumor Immunotherapy and Prevention”, ACS Nano, 2022, https://doi.org/10.1021/acsnano.2c09708

117. Yuena Wang, Rongtong Zhao, Chuan Wan, Xiaochun Guo, Fenfang Yang, Zhanfeng Hou, Rui Wang, Shuiming Li, Tiejian Feng*, Feng Yin*, and Zigang Li*, “A Peptide-Based Ligand-Directed Chemistry Enables Protein Functionalization”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c02974

116. Hailing Chen#, Meimiao Zhan#, Jianbo Liu#, Zhihong Liu, Minhong Shen, Fenfang Yang, Yibin Kang*, Feng Yin*, and Zigang Li*, “Structure-Based Design, Optimization, and Evaluation of Potent Stabilized Peptide Inhibitors Disrupting MTDH and SND1 Interaction”, Journal of Medicinal Chemistry, 2022, https://doi.org/10.1021/acs.jmedchem.2c00862

115. Jinpeng Wang#, Min Zhang#, Susheng Liu, Zhipeng He, Rui Wang, Minchan Liang, Yuhao An, Chenran Jiang, Chunli Song, Zigong Ning, Feng Yin, Hao Huang*, Zigang Li*, Yuxin Ye*, “Targeting UBE2C for degradation by bioPROTACs based on bacterial E3 ligase”, Chinese Chemical Letters, 2022, https://doi.org/10.1016/j.cclet.2022.08.012

114. Chuan Wan†, Yuena Wang†, Chenshan Lian†, Qi Chang, Yuhao An, Jiean Chen, Jinming Sun, Zhanfeng Hou, Dongyan Yang, Xiaochun Guo, Feng Yin*, Rui Wang* and Zigang Li*, “Histidine-Specific bioconjugation via visible-light-promoted thioacetal activation”, Chemical Science, 2022, https://doi.org/10.1039/D2SC02353A

Graphical abstract: Histidine-specific bioconjugation via visible-light-promoted thioacetal activation

113. Yuena Wang†, Rongtong Zhao†, Chuan Wan†, Wei Kang, Rui Wang, Chengyao Chiang, Xiaochun Guo, Qi Chang, Zhanfeng Hou, Yuxin Ye, Qinghong Luo, Ziyuan Zhou, Jianbo Liu, Shuiming Li, Dongyuan Wang*, Feng Yin* and Zigang Li*, “A proximity-triggered strategy towards transferable PROTACs”, CCS Chemistry, 2022, https://doi.org/10.31635/ccschem.022.202201985

112. Yao Tian†, Jianbo Liu†, Fadeng Yang, Chenshan Lian, Huawei Zhang, John H. Viles*, Zigang Li*, “Therapeutic potential for amyloid surface inhibitor: only amyloid-β oligomers formed by secondary nucleation disrupt lipid membrane integrity”, The FEBS Journal, 2022, https://doi.org/10.1111/febs.16550

111. Chuan Wan‡, Dongyan Yang‡, Xuan Qin, Ziyi Xue, Xiaochun Guo, Zhanfeng Hou, Chenran Jiang, Feng Yin*, Rui Wang*, Zigang Li*, “Flavin catalyzed desulfurization of peptides and proteins in aqueous media”, Organic & Biomolecular Chemistry, 2022, https://doi.org/10.1039/D2OB00641C

Graphical abstract: Flavin catalyzed desulfurization of peptides and proteins in aqueous media

110. Chuan Dai#, Chenshan Lian#, Huilong Fang, Qinhong Luo, Junrong Huang, Min Yang, Heng Yang, Lizhi Zhu*, Jinqiang Zhang*, Feng Yin*, and Zigang Li*, “Diversity-Oriented Synthesis of ERα Modulators via Mitsunobu Macrocyclization”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c01239

109. Qinqi Ren#, Yaping Zhang#, Shenhui Ma, Xiaofang Wang, Kuan-Chang Chang, Yiming Zhang, FengYin*, Zigang Li*, MinZhang*, “Low-temperature supercritical activation enables high-performance detection of cell-free DNA by all-carbon-nanotube transistor”, Carbon, 2022, https://doi.org/10.1016/j.carbon.2022.04.068

108. Rui Wang, Dongyan Yang, Tian Tian, Yuhao An, Chuan Wan, Qi Chang, Mingchan Liang, Zhanfeng Hou, Ying Wang, Liang Zhang*, and Zigang Li*, “Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells”, Analytical Chemistry, 2022, https://doi.org/10.1021/acs.analchem.1c05129

107. Mei-miao Zhan, Rui Wang, Zhihong Liu, Na Liu, Yuxin Ye, Mingchan Liang, Yichi Zhang, Chenran Jiang, Feng Yin*, and Zigang Li*, “Chemo-Selective Cys–Pen Disulfide for Proximity-Induced Cysteine Cross-Linking”, ACS Chemical Biology, 2022, https://doi.org/10.1021/acschembio.2c00083

106. Zhanfeng Hou,# Yuena Wang,# Chuan Wan,# Lijuan Song,# Rui Wang, Xiaochun Guo, Dongyan Yang, Yaping Zhang, Xuan Qin, Ziyuan Zhou, Xinhao Zhang,* Feng Yin,* and Zigang Li*, “Sulfonium Triggered Alkyne−Azide Click Cycloaddition”, Organic Letters, 2022, https://doi.org/10.1021/acs.orglett.2c00021

105. Xuan Qin, Rui Wang, Hongkun Xu, Licheng Tu, Hailing Chen, Heng Li, Na Liu,
Jinpeng Wang, Shuiming Li, Feng Yin*, Naihan Xu*& Zigang Li*, “Identification of an autoinhibitory, mitophagy-inducing peptide derived from the transmembrane domain of USP30”, Autophagy, 2022, https://doi.org/10.1080/15548627.2021.2022360


104. Na Liu,# Yichi Zhang,# Yingshou Lei,# Rui Wang, Meimiao Zhan, Jianbo Liu, Yuhao An, Yaoqi Zhou, Jian Zhan*, Feng Yin*, and Zigang Li* “Design and Evaluation of a Novel Peptide−Drug Conjugate Covalently Targeting SARS-CoV‑2 Papain-like Protease”, Journal of Medicinal Chemistry, 2022, https://doi.org/10.1021/acs.jmedchem.1c02022

103. Chuan Wan,# Yuan Feng,# Zhanfeng Hou,# Chenshan Lian, Liang Zhang, Yuhao An, Jinming Sun, Dongyan Yang, Chenran Jiang, Feng Yin,* Rui Wang,* and Zigang Li*”Electrophilic Sulfonium-Promoted Peptide and Protein Amidation in Aqueous Media”, Organic Letters, 2021, https://doi.org/10.1021/acs.orglett.1c04017

102. Li Duan*, Xiao Xu, Limei Xu, Caining Wen, Kan Ouyang, Zigang Li and Yujie Liang*. “ERα-Targeting PROTAC as a Chemical Knockdown Tool to Investigate the Estrogen Receptor Function in Rat Menopausal Arthritis”, Frontiers in Pharmacology, 2021, DOI: 10.3389/fphar.2021.764154

101. Shenhui Ma, Yaping Zhang, Qinqi Ren, Xiaofang Wang, Jiahao Zhu, Feng Yin*, Zigang Li*, Min Zhang*. “Tetrahedral DNA nanostructure based biosensor for high-performance detection of circulating tumor DNA using all-carbon nanotube transistor”, Biosensors and Bioelectronics, 2022, https://doi.org/10.1016/j.bios.2021.113785
Fig. 1

100. Junrong Huang, Min Yang, Chuan Dai, Yajun Zhou, Huilong Fang, Lizhi Zhu*, Feng Yin* and Zigang Li*. “Novel Strategies in C-H Oxidations for Natural Product Diversification-A Remote Functionalization Application Summary”, Frontiers in Chemistry, 2021, https://doi.org/10.3389/fchem.2021.737530

99.  Fenfang Yang, Feng Yin and Zigang Li, “Helical Stabilization of Peptide Macrocycles by Stapled Architectures”, Peptide Macrocycles. Methods in Molecular Biology, vol 2371. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1689-5_21

98. Rongtong Zhao,‡ Xiaodong Shi,‡ Linlin Shi, Hui Zhao, Feng Yin* and Zigang Li*, “Solid phase diversity-oriented lysine modification of cyclic peptides”, Journal of Peptide Science, 2021, https://doi.org/10.1002/psc.3373

97. Hongkun Xu,‡ Xuan Qin,‡ Yaping Zhang,‡ Chuan Wan, Rui Wang, Zhanfeng Hou, Xiaofeng Ding, Hailing Chen, Ziyuan Zhou, Yang Li, Chenshan Lian, Feng Yin,* and  Zigang Li* “A bifunctional vinyl-sulfonium tethered peptide constructed/induced by thio-Michael-type addition reaction“, Chinese Chemical Letters, 2021, https://doi.org/10.1016/j.cclet.2021.09.071

96. Kuan Hu,‡ Wenyu Wu,‡ Lin Xie, Hao Geng, Yiding Zhang, Masayuki Hanyu, Lulu Zhang, Yinghuan Liu, Kotaro Nagatsu , Hisashi Suzuki, Jialin Guo, Yundong Wu,* ZigangLi,* Feng Wang* and Mingrong Zhang* “Whole-body PET tracking of a D-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors”, Acta Pharmaceutica Sinica B, 2021, https://doi.org/10.1016/j.apsb.2021.09.016

95. Xuan Qin,‡ Hailing Chen,‡ Licheng Tu, Yue Ma, Na Liu, Haowei Zhang, Di Li, Bernd Riedl, Donald Bierer*, Feng Yin*, and Zigang Li* “Potent Inhibition of HIF1α and p300 Interaction by a Constrained Peptide Derived from CITED2”, Journal of Medicinal Chemistry, 2021, https://doi.org/10.1021/acs.jmedchem.1c01043

94. Yinghuan Liu, Kuan Hu, Feng Yin* and Zigang Li* “Facile Chemoselective Modification of Thioethers Generates Chiral Center-Induced Helical Peptides” Peptide Conjugation. Methods in Molecular Biology, 2021, vol 2355. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-1617-8_23 Link

93.  Zigang Li, Hui Zhao, Chuan Wan “Cyclized Helical Peptides: Synthesis, Properties, and Therapeutic Applications” Online ISBN:9783527343430 |DOI:10.1002/9783527343430 Link

92. Chenshan Lian,‡ Yang Li,‡ Zhanfeng Hou, Wanjin Zhong, Ye Tian, Feng Yin, Zigang Li,* Dongxian Zhou,* Rui Wang* “Proximity-induced amino-yne reaction for selective MDM4 conjugation via propargylated sulfonium” Chinese Chemical Letters, 2021, https://doi.org/10.1016/j.cclet.2021.04.015.

91. Yixiang Jiang,‡ Wan Zhang,‡ Fadeng Yang,‡ Chuan Wan, Xiang Cai, Jianbo Liu, Qianling Zhang, Zigang Li* and Wei Han* “Molecular design of stapled pentapeptides as building blocks of self-assembled coiled coil–like fibers” Science Advances, 2021, 7 (4): eabd0492. DOI: 10.1126/sciadv.abd0492

90. Ziyuan Zhou, Qing Pan, Xinchen Lv, Jing Yuan, Yang Zhang, Ming-Xia Zhang, Ming Ke, Xiao-Mei Mo, Yong-Li Xie, Yingxia Liu, Ting Chen, Mingchan Liang, Feng Yin, Lei Liu, Yiqing Zhou, Kun Qiao, Rui Liu, ZigangLi* and Nai-Kei Wong* “Structural insights into the inhibition of bacterial RecA by naphthalene polysulfonated compounds” iScience, 2021, 24, 101952, doi://doi.org/10.1016/j.isci.2020.101952

89. Wenjun Li,‡ Yaping Zhang,‡ Yanchao Wang,‡ Yue Ma, Dongyuan Wang, Heng Li, Xiyang Ye, Feng Yin and Zigang Li* “Nucleic acids induced peptide-based AIE nanoparticles for fast cell imaging” Chinese Chemical Letters, 2020, https://doi.org/10.1016/j.cclet.2020.09.054

88. Di Li, Tianqi Su, Lili Ma, Feng Yin, Weiguo Xu*, Jianxun Ding and ZigangLi* “Dual-acidity-labile polysaccharide-di-drugs conjugate for targeted cancer chemotherapy” Eur J Med Chem. 2020, 199:112367. Doi: 10.1016/j.ejmech.2020.112367.

87. Na Liu,‡ Dongyuan Wang,‡ Chenshan Lian,‡ Rongtong Zhao, Licheng Tu, Yichi Zhang, Jianbo Liu, Huilin Zhu, Mengying Yu, Chuan Wan, Di Li, Shuiming Li, Feng Yin* and Zigang Li* “Selective Covalent Targeting of Anti‐Apoptotic BFL‐1 by a Sulfonium Tethered Peptide” Chembiochem, 2020, DOI:10.1002/cbic.202000473, Link

86. Yang Li, Chenshan Lian, Zhanfeng Hou, Dongyuan Wang, Rui Wang, Chuan Wan, Wanjin Zhong, Rongtong Zhao, Yuena Wang, Shuiming Li, Feng Yin* and Zigang Li* “Intramolecular methionine alkylation constructs sulfonium tethered peptides for protein conjugation” Chemical Communications, 2020, DOI: 10.1039/D0CC00377H, Link

85. Kuan Hu, Wei Xiong, Chengjie Sun, Chan Wang, Jingxu Li, Feng Yin, Yixiang Jiang, Ming-Rong Zhang, Zhou Li, Xinwei Wang, and Zigang Li* “Self-Assembly of Constrained Cyclic Peptides Controlled by Ring Size” CCS Chemistry, 2020, DOI: https://doi.org/10.31635/ccschem.020.201900047, Link

84. Yi Wang,‡ Weirong Qin,‡ Hongdong Shi, Haijie Chen, Xiaoyan Chai, Jingang Liu*, Pingyu Zhang*, Zigang Li* and Qianling Zhang* “A HCBP1 peptide conjugated ruthenium complex for targeted therapy of hepatoma” Dalton Transactions, 2020, DOI: https://pubs.rsc.org/en/content/articlelanding/2020/DT/C9DT03856F, Link

83. Zhanfeng Hou‡, Dong-Yuan Wang‡, Yang Li, Rongtong Zhao, Chuan Wan, Yue Ma, Chenshan Lian, Feng Yin* and Zigang Li*”A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification” J. Org. Chem., 2020, DOI: https://doi.org/10.1021/acs.joc.9b02505, Link

82. Wenjun Li‡, Yubo Gao‡, Jiaona Zhang, Xiaofang Wang, Feng Yin*, Zigang Li*, Min Zhang* “Universal DNA detection realized by peptide based carbon nanotube biosensors ” Nanoscale Adv., 2019, DOI: 10.1039/C9NA00625G, Link

81. Fadeng Yang‡, Wan Zhang‡, Yixiang Jiang, Feng Yin*, Wei Han* and Zigang Li* “Targeting the amyloid-β fibril surface by constrained helical peptide inhibitor” Biochemistry 2019, DOI: https://doi.org/10.1021/acs.biochem.9b00800, Link

80. Wei Xiong‡, Kuan Hu‡, Zhe Li‡, Yixiang Jiang, Zigang Li*, Zhou Li*, Xinwei Wang* “A wearable system based on core-shell structured peptide-Co9S8 supercapacitor and triboelectric nanogenerator” Nano Energy, 2019, DOI: https://doi.org/10.1016/j.nanoen.2019.104149, Link

79. Licheng Tu, Dongyuan Wang, Zigang Li* “Design and Synthetic Strategies for Helical Peptides”, Cyclic Peptide Design, 2019, pp: 107-131 Link

78. Kuan Hu‡, Feng Yin‡, Ziyuan Zhou‡, Chenshan Lian, Yinghuan Liu, Chengjie Sun, Wenjun Li, Jianing Zhang and Zigang Li* “Directional assembly of a stapled α-helical peptide ” Chemical Communications, 2019, DOI: 10.1039/C9CC04591K Link

77. Yixiang Jiang‡, Xuehan Jiang‡, Xiaodong Shi, Fadeng Yang, Yang Cao, Xuan Qin, Zhanfeng Hou, Mingsheng Xie, Na Liu, Qi Fang, Feng Yin*, Wei Han*, Zigang Li* “α-helical motif as inhibitors of toxic amyloid-β oligomer generation via highly specific recognition of amyloid surface” iScience, 2019, DOI:  https://doi.org/10.1016/j.isci.2019.06.022 Link

76. Jianing Zhang‡, Yue Ma‡, Kuan Hu, Yuan Feng, Si Chen, Xiaoyang Yang, Jacky Fong-Chuen Loo, Han Zhang, Feng Yin* and Zigang Li* “Surface Coordination of Black Phosphorus with Modified Cisplatin” Bioconjugate Chemistry, 2019, DOI: 10.1021/acs.bioconjchem.9b00128 Link

75. Dongyuan Wang‡, Mengying Yu‡, Na Liu, Chenshan Lian, Zhanfeng Hou, Rui Wang, Rongtong Zhao, Wenjun Li, Yixiang Jiang, Xiaodong Shi, Shuiming Li*, Feng Yin*, Zigang Li* “A sulfonium tethered peptide ligand rapidly and selectively modifies protein cysteine in vicinity” Chemical Science, 2019, DOI: 10.1039/C9SC00034H Link

74. Qinsi Xiong†, Yixiang Jiang†, Xiang Cai, Fadeng Yang, Zigang Li*, and Wei Han* “Conformation Dependence of Diphenylalanine Self-Assembly Structures and Dynamics:Insights from Hybrid-Resolution Simulations” ACS Nano, 2019, DOI: 10.1021/acsnano.8b09741 Link

73. Dongyuan Wang, Wenjun Li, Rongtong Zhao, Longjian Chen, Na Liu, Yuan Tian, Hui Zhao, Mingsheng Xie, Fei Lu, Qi Fang, Wei Liang, Feng Yin and Zigang Li* “Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo” Cancer Research, 2019, DOI:  10.1158/0008-5472.CAN-18-1421. Link


72.Xuewen He†, Feng Yin†, Dongyuan Wang, Ling-Hong Xiong, Ryan T. K. Kwok, Peng Fei Gao, Zheng Zhao, Jacky W. Y. Lam, Ken-Tye Yong, Zigang Li*, and Ben Zhong Tang* “AIE Featured Inorganic–Organic Core @ Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring” Nano Letters, 2019, DOI:  10.1021/acs.nanolett.8b04677, Link


71. Xuan Qin,‡ Xiaodong Shi,‡ Licheng Tu, Yue Ma, Ziyuan Zhou, Rongtong Zhao, Meimiao Zhan, Feng Yin* and Zigang Li* “Autophagy inducing cyclic peptides constructed by methionine alkylation” Chemical Communications, 2019, DOI: 10.1039/C9CC01027K, Link

70. Yue Ma,‡ Wenjun Li,‡ Ziyuan Zhou, Xuan Qin, Dongyuan Wang, Yubo Gao, Zhiqiang Yu, Feng Yin*, and Zigang Li* “Peptide-Aptamer Coassembly Nanocarrier for Cancer Therapy” Bioconjugate Chemistry2019, Article ASAP, doi: 10.1021/acs.bioconjchem.8b00903, Link

69.  Na Liu,‡ Rongtong Zhao,‡ Yue Ma, Dongyuan Wang, Chen Yan, Dongxian Zhou*, Feng Yin*, Zigang Li* “The Development of Epigenetics and Related Inhibitors for Targeted Drug Design in Cancer Therapy” Current Topics in Medicinal Chemistry, 2018, 18(28): 2380 – 2394, doi:10.2174/1568026618666181115092623, Link

68. Xiaodong Shi, Kuan Hu, Hao Geng, Zhihong Liu, Feng Yin* and Zigang Li* “Effects of chiral center on an all‐hydrocarbon tethered peptide” Peptide Science, 2018, https://doi.org/10.1002/pep2.24110, Link


67. Xiaodan Cai, Weihao Zheng, Xiaodong Shi, Longjian Chen, Zhihong Liu, and Zigang Li *”HBx-derived constrained peptides inhibit the secretion of hepatitis B virus antigens”Mol. Pharmaceutics, 2018,Article ASAP, DOI: 10.1021/acs.molpharmaceut.8b00807, Link

66. Zhanfeng Hou, Chengjie Sun, Hao Geng, Kuan Hu, Mingsheng Xie, Yue Ma, Fan Jiang,* Feng Yin,* and Zigang Li* “Facile Chemoselective Modification of Thio-Ethers Generates Chiral Center-Induced Helical Peptides ” Bioconjugate Chemistry, 2018, Article ASAP DOI: 10.1021/acs.bioconjchem.8b00624, Link

65. Dan Yang,‡ Weirong Qin,‡ Xiaodong Shi, Bili Zhu, Mingsheng Xie, Hui Zhao, Bin Teng, Yujie Wu, Rongtong Zhao, Feng Yin, Pei-Gen Ren, Lizhong Liu, and Zigang Li* “Stabilized β-hairpin peptide inhibits insulin degrading enzyme” Journal of Medicinal Chemistry, 2018, doi:10.1021/acs.jmedchem.8b00418, Link

64. Xiaodong Shi,‡ Yinghuan Liu,‡ Rongtong Zhao, Zigang Li* “Constructing Thioether/Vinyl Sulfide-tethered Helical Peptides Via Photo-induced Thiol-ene/yne Hydrothiolation” Journal of Visualized Experiments, 2018, doi:10.3791/57356, Link

63. Fang Yuan,‡ Yuan Tian,‡ Weirong Qin,‡ Jingxu Li, Dan Yang, Bingchuan Zhao, Feng Yin* and Zigang Li * “Evaluation of topologically distinct constrained antimicrobial peptides with broad-spectrum antimicrobial activity” Organic & Biomolecular Chemistry, 2018, doi: 10.1039/C8OB00483H Link

62. Weirong Qin,‡ Mingsheng Xie,‡ Xuan Qin, Qi Fang, Feng Yin,* Zigang Li* “Recent Advances in Peptidomimetics Antagonists Targeting Estrogen Receptor α-Coactivator Interaction in Cancer Therapy” Bioorganic & Medicinal Chemistry Letters, 2018, doi: https://doi.org/10.1016/j.bmcl.2018.05.062 Link

61. Wenjun Li, Dongyuan Wang, Xiaodong Shi, Jingxu Li, Yue Ma, Yanding Wang, Tingting Li, Jianing Zhang, Rongtong Zhao, Zhiqiang Yu, Feng Yin* and Zigang Li* “A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy ” Materials Horizons, 2018, doi: 10.1039/C8MH00392K Link

60. Jianing Zhang, Si Chen, Yue Ma, Dongyuan Wang, Jian Zhang, Yanding Wang, Wenjun Li, Zhiqiang Yu, Han Zhang, Feng Yin and Zigang Li* “Organosilicon modification enhanced the stability of black phosphorus nanosheets at ambient conditions ”  J. Mater. Chem. B, 2018, doi: 10.1039/C8TB01349G Link 

59. Kuan Hu,‡ Yixiang Jiang,‡ Wei Xiong, Hu Li, Pei-Yu Zhang, Feng Yin, Qianling Zhang, Hao Geng, Fan Jiang,* Zhou Li,* Xinwei Wang,* and Zigang Li* “Tuning peptide self-assembly by an in-tether chiral center” Science Advances, 2018, doi: 10.1126/sciadv.aar5907 Link

58. Weihao Zheng, Xiaodan Cai, Shuiming Li and Zigang Li* “Autophosphorylation Mechanism of the Ser/Thr Kinase Stk1 From Staphylococcus aureus” Front. Microbiol., 2018, https://doi.org/10.3389/fmicb.2018.00758 Link


57. Xuan Qin, Hui Zhao, Yanhong Jiang, Feng Yin, Yuan Tian, Mingsheng, Xie, Xiyang Ye, Naihan Xu, Zigang Li* “Development of a potent peptide inhibitor of estrogen receptor α”  Chinese Chemical Letters, 2018, https://doi.org/10.1016/j.cclet.2018.04.004

56.  Xiaodong Shi, Rongtong Zhao, Yixiang Jiang, Hui Zhao, Yuan Tian, Yanhong Jiang, Jingxu Li, Weirong Qin, Feng Yin*,  Zigang Li* “Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation ” Chem. Sci., 2018, DOI: 10.1039/C7SC05109C. Link

55. Wenjun Li,‡ Kuan Hu,‡ Qingzhou Zhang, Dongyuan Wang, Yue Ma, Zhanfeng Hou, Feng Yin*, Zigang Li* “N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties ”  Chem. Commun. 2018; doi: DOI: 10.1039/C7CC09201F. Link

54. Yanhong Jiang,† Qiwen Deng,† Hui Zhao, Mingsheng Xie, Longjian Chen, Feng Yin, Xuan Qin, Weihao Zheng, Yongjuan Zhao* and Zigang Li* “Development of stabilized peptide-based PROTACs against estrogen receptor α” Acs Chemical Biology, 2017;  doi: 10.1021/acschembio.7b00985 Link

53. Weihao Zheng, Xiaodan Cai and Zigang Li* “Anti-virulence targets of Staphylococcus aureus” Research Trend on Bacterial Pathogenesis. 2017; ISBN:978-1-922227-77-5. iConcept Press.


52.Xiaodan Cai,† Weihao Zheng,† Zigang Li* “High-Throughput Screening Strategies for the Development of Anti-Virulence Inhibitors against Staphylococcus aureus” Current Medicinal Chemistry, 2017; doi: 10.2174/0929867324666171121102829


51. Xiaodan Cai,Weihao Zhenga,Shaokun Pan, Shengyuan Zhang, Youhua Xie, Haitao Guo, Guoxin Wang,∗ Zigang Li,∗ Ming Luo∗ “A virus-like particle of the hepatitis B virus preS antigen elicits robust neutralizing antibodies and T cell responses in mice” Antiviral Research, 2017; doi: 10.1016/j.antiviral.2017.11.007

50. Mingsheng Xie, Hui Zhao, Qisong Liu, Yujia Zhu, Feng Yin, Yujie Liang, Yanhong Jiang, Dongyuan Wang, Kuan Hu, Xuan Qin, Zichen Wang, Yujie Wu, Naihan Xu, Xiyang Ye* , Tao Wang* , and Zigang Li* “Structural Basis of Inhibition of ERα-Coactivator Interaction by High-Affinity N‑Terminus Isoaspartic Acid Tethered Helical Peptides” J. Med. Chem., 2017; 60 (21), pp 8731–8740; doi: 10.1021/acs.jmedchem.7b00732

49. Kuan Hu,† Feng Yin1,† Mengyin Yu, Chengjie Sun, Jingxu Li, Yujie Liang, Wenjun Li, Mingsheng Xie, Yuanzhi Lao, Wei Liang* , Zigang Li* “In-tether chiral center induced helical peptide modulators target p53-MDM2/MDMX and inhibit tumor growth in stem-like cancer cell” Theranostics, 2017; 7(18):4566-4576; doi:10.7150/thno.19840 Link

48. Yuan Tian,† Xiangze Zeng, †Jingxu Li, †Yanhong Jiang, Hui Zhao, Dongyuan Wang, Xuhui
Huang* and Zigang Li* “Achieving enhanced cell penetration of short conformationally
constrained peptides through amphiphilicity tuning” Chemical Science, 2017; doi:  10.1039/C7SC03614K Link

47. Yuan Tian, † Yanhong Jiang, † Jingxu Li,  Dongyuan Wang, Hui Zhao,  Zigang Li* “Effect of stapling architecture on physiochemical properties and cell permeability of stapled -helical peptides: a comparative study” ChemBioChem.2017; doi:10.1002/cbic.201700352 Link

46. Jingxu Li, Kuan Hu, Hailing Chen, YuJie Wu, Longjian Chen, Feng Yin,* Yuan Tian,* and Zigang Li* “In-tether chiral center modulates the proapoptotic activity of KLA peptide” Chem. Commun. 2017; doi: 10.1039/C7CC04923D Link

45.Dan Yang,‡ “Development of a high quantum yield dye for tumour imaging” Chemical Science, 2017; doi: 10.1039/c7sc02698f Link

44. Hui Zhao, ‡ Xuan Qin, ‡ Dan Yang, ‡ Yanhong Jiang, Weihao Zheng, Dongyuan Wang, Yuan Tian, Qisong Liu, Naihan Xu* and Zigang Li* “The development of activatable lytic peptides for targeting triple negative breast cancer”  Cell Death Discovery,2017; doi:10.1038/cddiscovery.2017.37 Link


43. Xiaodong Shi, ‡ Yixiang Jiang, ‡ Dan Yang, Hui Zhao, Yuan Tian, Zigang Li* “Reversibly switching the conformation of short peptide through in-tether chiral sulfonium auxiliary”  Chinese Chemical Letters, 2017; doi:10.1016/j.cclet.2017.07.003 Link


42.  Feng Yin, ‡ Kuan Hu, ‡ Si Chen,‡ Dongyuan Wang, Jianing Zhang, Mingsheng Xie, Dan Yang, Meng Qiu, Han Zhang* and Zi-gang Li* “Black phosphorus quantum dot based novel siRNA delivery systems in human pluripotent teratoma PA-1 cells”  J. Mater. Chem. B, 2017; doi:10.1039/c7tb01068k Link


41. Kuan Hu,‡, Chengjie Sun,‡, Zigang Li,* “Reversible and versatile on-tether modification of chiral center-induced helical peptides”  Bioconjugate Chem. 2017; doi:10.1021/acs.bioconjchem.7b00321  Link


40. Kuan Hu,‡ Chengjie Sun,‡ Dan Yang,‡ Yujie Wu, Chuan Shi, Longjian Chen, Tao Liao, Jialin Guo, Yinghuan Liu and Zigang Li* “A precisely positioned chiral center in an i, i +7 tether modulates the helicity of the backbone peptide” Chem. Commun. 2017; doi: 10.1039/c7cc03799f Link


39. Kuan Hu,‡ Chengjie Sun,‡ Mengying Yu, Wenjun Li, Huacan Lin, Jialin Guo, Yixiang Jiang, Chengxiang Lei, and Zigang Li* “Dual in-tether chiral centers modulate peptide helicity” Bioconjugate Chem. 2017; doi: 10.1021/acs.bioconjchem.7b00171 Link


38. Yanhong Jiang, Hui Zhao, Yuan Tian, Zigang Li* “Lipid–cell-penetrating-peptide conjugates as effective delivery systems” Synlett2017; doi:10.1055/s-0036-1588807 Link无标题37. Dongyuan Wang, Xuan Qin, Hui Zhao, Zigang Li* “N-Cap helix nucleation: methods and their applications ” Sci. CHINA Chem. , 2017 ; doi: 10.1007/s11426-016-9033-y Link                                                     

36. Yuan Tian,‡ Dan Yang,‡ Xiyang Ye and Zigang Li* “Thioether-derived macrocycle for peptide secondary structure fixation” Chem. Rec. , 2017;17,1–13. doi:10.1002/tcr.201600137 Link


35. Feng Yin,‡ Kuan Hu,‡ Yangzi Chen, Mengying Yu, Dongyuan Wang, Qianqian Wang, Ken-Tye Yong, Fei Lu, Yongye Liang , Zigang Li*SiRNA delivery with PEGylated graphene oxide nanosheets for combined photothermal and genetherapy for pancreatic cancerTheranostics, 2017; 7(5):1133-1148. doi:10.7150/thno.17841 Link


34. Hui Zhao, Yanhong Jiang, Yuan Tian, Dan Yang, Xuan Qin and Zigang Li* “Improving cell penetration of helical peptides stabilized by N-terminal crosslinked aspartic acids” Organic & Biomolecular Chemistry,2016, DOI: 10.1039/c6ob02501c Link


33. Yixiang Jiang, Kuan Hu, Xiaodong Shi, Qingzhuang Tang, ZiChen Wang, Xiyang Ye* and Zigang Li* “Switching substitution groups on the in-tether chiral centre influences backbone peptides’ permeability and target binding affinity” Organic & Biomolecular Chemistry,2016, DOI: 10.1039/c6ob02289h Link

Graphical abstract: Switching substitution groups on the in-tether chiral centre influences backbone peptides’ permeability and target binding affinity

32. Qingzhou Zhang, Fan Jiang, Bingchuan Zhao, Huacan Lin, Yuan Tian, Mingsheng Xie, Guoyun Bai, Adam M. Gilbert, Gilles H. Goetz, Spiros Liras, Alan A. Mathiowetz, David A. Price, Kun Song, Meihua Tu, Yujie Wu, Tao Wang,*, Mark E. Flanagan,*,  Yun-Dong Wu* & Zigang Li* “Chiral sulfoxide-induced single turn peptide α-helicity ” Scientific Reports, 2016, DOI:10.1038/srep38573 Link


31. Jingxu Li, Yuan Tian, Dongyuan Wang, Yujie Wu, Xiyang Ye*, Zigang Li* “An in-tether sulfoxide chiral center influences the biophysical properties of the N-capped peptides” Bioorganic & Medicinal Chemistry, 2016, DOI: http://dx.doi.org/10.1016/j.bmc.2016.11.042 Link

Image for unlabelled figure

30. Kuan Hu,‡ Wenjun Li,‡ Mengying Yu, Chengjie Sun, and Zigang Li* “Investigation of cellular uptakes of the in-tether chiral-center-induced helical pentapeptides”  Bioconjugate Chem, 2016, DOI: 10.1021/acs.bioconjchem.6b00492 Link


29. Tao Liao,‡ Fang Yuan,‡ Chuan Shi, Chuan-Xin He* and Zigang Li* “Lanthanide chelate-encapsulated polystyrene nanoparticles for rapid and quantitative immunochromatographic assay of procalcitonin” RSC Advances,2016, 6, 103463, DOI: 10.1039/c6ra23816e Link


28. Huacan Lin, Yixiang Jiang, Kuan Hu, Qingzhou Zhang, Chuanxin He*, Tao Wang* and Zigang Li*  “An in-tether sulfilimine chiral center induces β-turn conformation in short peptidesOrganic & Biomolecular Chemistry, 2016, DOI: 10.1039/C6OB01805 Link

image file: c6ob01805j-f1.tif

27. Hui Zhao‡ , Qi-Song Liu‡ , Hao Geng‡ , Yuan Tian, Min Cheng, Yan-Hong Jiang, MingSheng Xie, Xiao-Gang Niu, Fan Jiang, Ya-Ou Zhang, Yuan-Zhi Lao, Yun-Dong Wu,* NaiHan Xu,* and Zi-Gang Li* “Crosslinked aspartic acids as helix-nucleating templates” Angew. Chem.Int. Ed.2016 DOI: 10.1002/ange.201606833 Link


26. Weihao Zheng, Xiaodan Cai, Mingsheng Xie,Yujie Liang, Tao Wang* and Zigang Li*”Structure-based-identification of a potent inhibitor targeting stp1-mediated virulence regulation in staphylococcus aureus” Cell Chemical Biology, 2016, http://dx.doi.org/10.1016/j.chembiol.2016.06.014 Link


25. Huacan Lin, Yixiang Jiang, Qingzhou Zhang, Kuan Hu and Zigang Li* “An in-tether sulfilimine chiral center induces helicity in short peptides” Chem. Commun. 2016 DOI: 10.1039/C6CC04508A Link

Graphical abstract: An in-tether sulfilimine chiral center induces helicity in short peptides

24. Bingchuan Zhao, Qingzhou Zhang and Zigang Li* “Constructing thioether-tethered cyclic
peptides via on-resin intra-molecular thiol–ene reaction”  Journal of Peptide Science. 2016 DOI : 10.1002/psc.2902 Link

Figure for Graphical Abstract

23. Yuan Tian,‡ Dongyuan Wang,‡  Jingxu Li, Chuan Shi, Hui Zhao, Xiaogang Niu and Zigang Li* “A proline-derived transannular N-cap for  nucleation of short a-helical peptides” Chem. Comm. 2016 DOI: 10.1039/c6cc04672j Link

Graphical abstract: A proline-derived transannular N-cap for nucleation of short α-helical peptides

22. Bingchuan Zhao,‡ Dan Yang,‡ Jack Ho Wong, Jianpeng Wang, Cuiming Yin, Yuxia Zhu, Shangrong Fan*, Tzi Bun Ng*, Jiang Xia* and  Zigang Li* “A Thioether-Stabilized d-Proline–l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability” ChemBioChem. 2016 DOI: 10.1002/cbic.201600179 Link

TOC Graphic

21. F. Yuan, Y. Deng, W. Zhou, M. Zhang, Z. Li. ” A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field- effect transistors “, Nano Res. 2016, 9, 1701-1708 Link


20. Y. Deng,‡ F. Yuan,‡ W. Zhou, M. Zhang, Z. Li. ” Highly uniform DNA biosensors based on threshold voltage of carbon nanotube thin-film transistors “, Nano. 2016, 11, 1650060.  Link

19. T. Liao, F. Yuan, H. Yu and Z. Li. ” A ultrasensitive ELISA method for detection of procalcitonin based on magnetic beads and enzyme-antibody labeled gold nanoparticles “, Anal. Methods. 2016, 8, 1577-1585. (co-first author) Link

Graphical abstract: An ultrasensitive ELISA method for the detection of procalcitonin based on magnetic beads and enzyme-antibody labeled gold nanoparticles

18. Y. Wang, Z. Xia, S. Du, F. Yuan, Z. Li, Z. Li, Q. Dai, H. Wang, S. Lou, S. Zhang, H. Zhou. ” Solution-processed photodetectors based on organic-inorganic hybrid perovskite and nanocrystalline graphite “, Nanotechnology. 2016, 27, 175201  Link

17. Kuan Hu, Hao Geng, Qingzhou Zhang, Qisong Liu, Mingsheng Xie, Chengjie Sun, Wenjun Li,Huacan Lin, Fan Jiang, Tao Wang,* Yun-Dong Wu,* and Zigang Li*  An In-tether Chiral Center Modulates the Helicity, Cell Permeability,and Target Binding Affinity of a Peptide. Angew. Chem.Int. Ed.2016,DOI: 10.1002/anie.201602806R1.Link

16. Yuan Tian, Jingxu Li, Hui Zhao, Xiangze Zeng, Dongyuan Wang, Qisong Liu, Xiaogang Niu, Xuhui Huang, Naihan Xu* and Zigang Li* Stapling of unprotected helical peptides via photoinduced intramolecular thiol–yne hydrothiolation† Chem. Sci., 2016, Advance Article.Link

Graphical abstract: Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

15. Q Liu, H Zhao, Y Jiang, M Wu, Yuan Tian, D Wang, Y Lao, N Xu* & Z Li* Development of a lytic peptide derived from BH3-only proteins. Cell Death Discovery (2016) 2, 16008; Link

Figure 1

14. Bingchuan Zhao, Huacan Lin, Dan Yang, Xiyang Ye* and Zigang Li* Disulfide Bridges in Defesins  Curr.Top.Med.Chem.2015;16(2):206-19. Link

13. Yujie Wang, Hong Zhang, Qingzhou Zhang, Yujie Liang, Lin Ma, Hongsheng Tan, Yuanzhi Lao,* Hongxi Xu* and Zigang Li*  Genetically encoded fluorescence screening probe for MgrA, a global regulator in Staphylococcus aureus†   RSC Adv., 2015, 5, 87216–87220. Link

Graphical abstract: Genetically encoded fluorescence screening probe for MgrA, a global regulator in Staphylococcus aureus

12. Zhao, W. 1; Qian, H. 1; Li, Z.*; Sun, J.* (1: equal contribution) Catalytic Ring Expansion of Cyclic Hemiaminals for the Synthesis of Medium Ring Lactams.
Angew. Chem., Int. Ed. 2015, 54, 10143-10146. Link


11. Weihao Zheng, Yujie Liang, Hui Zhao, Jianing Zhang,  Zigang Li*., 5,5′-Methylenedisalicylic Acid (MDSA) Modulates SarA/MgrA Phosphorylation by Targeting Ser/Thr Phosphatase Stp1., ChemBioChem., 2015, 16, 1035-1040. Link


10. Qisong Liu, Fang Yuan, YuJie Liang, Zigang Li*., Cadmium adsorption by E. coli with surface displayed CadR., RSC Adv., 2015, 5, 16089-16092. Link


9. Qingzhou Zhang, Yuan Tian, Yuanzhi lao, Zigang Li*., Peptides-Staple Method Development and Its Application in Cancer Therapy., Curr. Med. Chem., 2014, 21, 2438-2452. Link

Abstract: α-Helixes are important structural motifs of protein three dimension structures and are largely involved in protein- protein interactions. This review covers the recent advances of the peptide stabilizing methodologies and introduces their applications in cancer research.

8. Qingzhou Zhang, Xiaodong Shi, Yanhong Jiang, Zigang Li*., Influence of α-methylation in constructing stapled peptides with olefin metathesis., Tetrahedron., 2014, 42, 7621-7626. Link


7.  Wenbo Sun, Huacan Lin, Wenyu Zhou* and Zigang Li*., Oxidative ortho-amino-methylation of phenols via C-H and C-C bond cleavage., RSC Adv., 2014, 4, 7491-7494. Link


6. Lianbo Li, Weili Zhang, Qisong Liu, Yu Gao, Ying Gao, Yun Wang, David Zhigang Wang, Zigang Li and Tao Wang*., Structural Insights on the Bacteriolytic and Self-protection Mechanism of Muramidase Effector Tse3 in Pseudomonas aeruginosa., J. Bio. Chem., 2013, published online. Link



5. Bing-Chuan Zhao, Qing-Zhou Zhang, Wen-Yu Zhou, Hu-Chun Tao* and Zi-Gang Li*., Silver catalyzed synthesis of 4-trifluoromethyl substituted quinolines in water., RSC Adv., 2013, 3, 13106-13109 Link


4. Wanxiang Zhao, Zigang Li*, and Jianwei Sun *., A New Strategy for Efficient Synthesis of Medium and Large Ring Lactones without High Dilution or Slow Addition., J. Am. Chem. Soc., 2013, 135 (12), 4680–4683 Link



3.  Shunyou Cai, Xinyang Zhao, Xinbo Wang, Qisong Liu, Prof. Dr. Zigang Li*, Prof. Dr. David Zhigang Wang*., Visible-Light-Promoted C-C Bond Cleavage: Photocatalytic Generation of Iminium Ions and Amino Radicals, Angew. Chem. 2012,51(32), 8050-8053 Link


2.  Yu-Ming Zhao, Yik Tam, Yu-Jie Wang, Zigang Li, and Jianwei Sun*., N-Heterocyclic Carbene-Catalyzed Internal Redox Reaction of Alkynals: An Efficient Synthesis of Allenoates, Org. Lett. 2012, 14(6), 1398-1401 Link



1. Fei Sun, Lu Zhou, Bing-Chuan Zhao, Xin Deng, Hoonsik Cho, Chengqi Yi, Xing Jian, Chun-Xiao Song, Chi-Hao Luan, Taeok Bae, Zigang Li*and Chuan He* ., Targeting MgrA-Mediated Virulence Regulation in Staphylococcus aureus., Chemistry & Biology 2011,18, 1032-1041 Link



Before 2011
Yang, S.; Li, Z.; Jian, X.; He, C. Platinum(II)-Catalyzed Intramolecular Cyclization of o -Substituted Aryl Alkynes through sp3 C—H Activation. Angew. Chem. Int. Ed. 2009, 48 (22), 3999–4001. DOI link
Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Hicks, L. M.; Dinner, A. R.; He, C. The Pseudomonas Aeruginosa Multidrug Efflux Regulator MexR Uses an Oxidation-Sensing Mechanism. Proc. Natl. Acad. Sci. 2008, 105 (36), 13586–13591. DOI link
Li, Z.; Brouwer, C.; He, C. Gold-Catalyzed Organic Transformations. Chem. Rev. 2008, 108 (8), 3239–3265. DOI link
Chang, S.; Bray, S. M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. Identification of Small Molecules Rescuing Fragile X Syndrome Phenotypes in Drosophila. Nat. Chem. Biol. 2008, 4 (4), 256–263. DOI link
Li, Z.; Capretto, D. A.; Rahaman, R. O.; He, C. Gold(III)-Catalyzed Nitrene Insertion into Aromatic and Benzylic C−H Groups. J. Am. Chem. Soc. 2007, 129 (40), 12058–12059. DOI link
Li, Z.; Capretto, D. A.; Rahaman, R.; He, C. Silver-Catalyzed Intermolecular Amination of C—H Groups. Angew. Chem. Int. Ed. 2007, 46 (27), 5184–5186. DOI link
Li, Z.; He, C. Recent Advances in Silver‐Catalyzed Nitrene, Carbene, and Silylene‐Transfer Reactions. Eur. J. Org. Chem. 2006, 2006 (19), 4313–4322. DOI link
Li, Z.; Zhang, J.; Brouwer, C.; Yang, C.-G.; Reich, N. W.; He, C. Brønsted Acid Catalyzed Addition of Phenols, Carboxylic Acids, and Tosylamides to Simple Olefins. Org. Lett. 2006, 8 (19), 4175–4178. DOI link
Li, Z.; Ding, X.; He, C. Nitrene Transfer Reactions Catalyzed by Gold Complexes. J Org Chem 2006, 71 (16), 5876–5880. DOI link
Li, Z.; Shi, Z.; He, C. Addition of Heterocycles to Electron Deficient Olefins and Alkynes Catalyzed by Gold(III). J. Organomet. Chem. 2005, 690 (23), 5049–5054. DOI link
Luo, Y.; Li, Z.; Li, C.-J. A Silver-Catalyzed Domino Route toward 1,2-Dihydroquinoline Derivatives from Simple Anilines and Alkynes. Org. Lett. 2005, 7 (13), 2675–2678. DOI link
Wei, C.; Li, Z.; Li, C.-J. The Development of A3-Coupling (Aldehyde-Alkyne-Amine) and AA3-Coupling (Asymmetric Aldehyde-Alkyne-Amine). Synlett 2004, 2004 (9), 1472–1483. DOI link
Li, Z.; Wei, C.; Chen, L.; Varma, R. S.; Li, C.-J. Three-Component Coupling of Aldehyde, Alkyne, and Amine Catalyzed by Silver in Ionic Liquid. Tetrahedron Lett. 2004, 45 (11), 2443–2446. DOI link
Wei, C.; Li, Z.; Li, C.-J. The First Silver-Catalyzed Three-Component Coupling of Aldehyde, Alkyne, and Amine. Org. Lett. 2003, 5 (23), 4473–4475. DOI link
Chen, L.; Li, Z.; Li, C.-J. Indium-Mediated Domino Reaction of Nitroarenes with 2,3-Dihydrofuran in Water: An Efficient Synthesis of 1,2,3,4-Tetrahydroquinoline Derivatives. Synlett 2003, 2003 (5), 732–734. DOI link
Li, Z.; Zhang, J.; Li, C.-J. InCl3-Catalyzed Reaction of Aromatic Amines with Cyclic Hemiacetals in Water: Facile Synthesis 1,2,3,4-Tetrahydroquinoline Derivatives. Tetrahedron Lett. 2003, 44 (1), 153–156. DOI link
4. Li, Z.; Capretto, D. A.; He, C. “Silver catalyzed nitrene transfer reactions.” Silver in Organic Chemistry,wiley in press
3. Li, Z.; Capretto, D. A.; He, C. “Gold-catalyzed additions to alkenes: N  nucleophiles” Modern Gold Catalyzed Synthesis, wiley submitted
2. Li, Z.; Capretto, D. A.; He, C. “Gold-catalyzed additions to alkenes: O nucleophiles” Modern Gold Catalyzed Synthesis, wiley submitted
1. Capretto, D. A.; Li, Z.; He, C. “Cyclization by C-H activation” Handbook of Cyclization Reactions, wiley, published
2. Li, Z. et al. “Oxidation turns on the global regulator SarA in Staphylococcus aureus”
1. Li, Z. et al. “Small molecule inhibitor of global regulator MgrA tunes down the virulence of Staphylococcus aureus”