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Zigang Li 

Principle Investigator, Associate Professor

   E-mail:                               lizg@pkusz.edu.cn
Telephone:                              0755-26033616
2009-2010    National Cancer Center Postdoctoral Fellow, Harvard University
2004-2008    Ph.D. Chemistry, The University of Chicago
2001-2004    M.S. Chemistry, Tulane University
1996-2001    B.S. Biophysics, The University of Science and Technology of China
2010-June         Principal Investigator, Ph.D. Advisor
                           The School of Chemical Biology and Biotechnology
                           Peking University, Shenzhen Graduate School
2009-2010         National Cancer Center Postdoctoral Fellow
                           Advisor:  Professor Gregory L. Verdine
                           Department of Chemistry, Harvard University, Cambridge, MA
                           New targets from human cancer cells for stapled peptides
2004-2008         Research Assistant, Advisor:  Professor Chuan He
                           Department of Chemistry, The University of Chicago, Chicago, IL
                           Investigation of global regulator functions on the pathogenesis of Staphylococcus aureus.
                           Development and discovery of transition metal catalyzed nitrene transfer reactivity
2001-2004         Research Assistant, Advisor:  Professor Chao-Jun Li
                           Department of Chemistry, Tulane University, New Orleans, LA
                           Investigation of imine reactivity in aqueous media
2009-2010          National Cancer Center Postdoctrol Fellowship, Harvard University
2008-2009          Harper Dissertation Fellowship, University of Chicago
2008                    The 12th GLCACS Annual Conference Student Poster Prize
2003                    Trebellas Outstanding Teaching Assistant Award, Tulane University
1996                    First prize, National Olympic Chemistry Competition, China
17.       Yang, S.; Li, Z.; Jian, X.; He, C.Platinum(II)-catalyzed intramolecular cyclization of o-substituted arylalkynes via sp3 C-H activation"Angew. Chem. Int. Ed. 2009, 2009, 48, 3999-4001.
16.       Li, Z.; Capretto, D. A.; He, C. “Silver mediated oxidation reactions:  recent advances and new prospects.”Prog. Inorg. Chem.  2009, 56, 1-48.
15.      Chen, H.; Hu, J.; Chen, P. R.; Lan, L.; Li, Z.; Dinner, A. R.; He, C. “The   multidrug efflux regulator MexR uses an oxidation sensing mechanism.” Proc. Natl. Acad. Sci. U. S. A.  2008, 105, 13586-13591.
14.       Li, Z.; Brouwer, C.; He, C. “Gold catalyzed organic transformations. Chem. Rev. 2008, 108, 3239-3265.
13.      Chang, S.; Bray, S. M.; Li, Z.; Zarnescu, D. C.; He, C.; Jin, P.; Warren, S. T. “Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.” Nature Chem. Biol. 2008, 4, 256-263.
12.       Li, Z.; Capretto, D. A.; Rahaman, R. O.; He, C. “Gold(III)-Catalyzed Nitrene Insertion into Aromatic and Benzylic C-H Groups.J. Am. Chem. Soc. 2007, 129, 12058-12059.
11.     Li, Z.; Capretto, D. A.; Rahaman, R. O.; He, C. “Silver-Catalyzed Intermolecular Amination of C-H Groups.” Angew. Chem. Int. Ed. 2007, 46, 5184-5186.
10.      Li, Z.; Zhang, J.; Brouwer, C.; Yang, C.-G.; Reich, N. W.; He, C. “Bronsted Acid Catalyzed Addition of Phenols, Carboxylic Acids, and Tosylamides to Simple Olefins.”Org. Lett. 2006, 8, 4175-4178.
9.        Li, Z.; He, C. “Recent Advances in Silver-Catalyzed Nitrene, Carbene, and Silylene-Transfer Reactions.”Eur. J. Org. Chem. 2006, 19, 4313-4322.
8.        Li, Z.; Ding, X.; He, C. Nitrenetransfer reactions catalyzed by gold complexes.” J. Org. Chem. 2006, 71, 5876-5880.
7.      Li, Z.; Shi, Z.; He, C. “Addition of heterocycles to electron deficient olefins and alkynes catalyzed by gold(III). J. Organometallic Chem. 2005, 690, 5049-5054.(most cited 2005-2008)
6.        Luo, Y.; Li, Z.; Li, C.-J. “A silver-catalyzed domino route toward 1,2-dihydroquinoline derivatives from simple anilines and alkynes.Org. Lett. 2005, 7, 2675-2678.
5.        Li, Z.; Wei, C. M.; Chen, L.; Varma, R. S.; Li, C. J. “Three component coupling of aldehyde, alkyne and amine catalyzed by silver in ionic liquid.” Tetrahedron Lett. 2004, 45, 2443-2446.
4.         Wei, C.; Li, Z.; Li, C.-J. The development of A3-coupling (aldehyde -alkyne-amine) and AA3-coupling (asymmetric aldehyde alkyne-amine).” Synlett 2004, 9, 1472-1483.
3.         Wei, C. M.; Li, Z.; Li, C.-J. “The first silver-catalyzed three-component -coupling of aldehyde, alkyne, and amines.” Org. Lett. 2003, 5, 4473-4475.
2.        Chen, L.; Li, Z.; Li, C.-J. “Indium-mediated domino reaction of nitroarenes with 2,3-dihydrofuran in water: an efficient synthesis of 1,2,3,4-tetrahydroquinoline derivatives.”Synlett 2003, 5, 732-734.
1.        Li, Z.; Zhang, J.; Li, C.-J. “InCl3-catalyzed reaction of aromatic amines with cyclic hemiacetals in water: facile synthesis of 1,2,3,4-tetrahydroquinoline derivatives. Tetrahedron Lett. 2003, 44, 153-156.
4.Li, Z.; Capretto, D. A.; He, C. “Silver catalyzed nitrene transfer reactions.” Silver in Organic Chemistry,wiley in press
3.Li, Z.; Capretto, D. A.; He, C. “Gold-catalyzed additions to alkenes: N  nucleophiles” Modern Gold Catalyzed Synthesis, wiley submitted
2.Li, Z.; Capretto, D. A.; He, C. “Gold-catalyzed additions to alkenes: O nucleophiles” Modern Gold Catalyzed Synthesis, wiley submitted
1.Capretto, D. A.; Li, Z.; He, C. “Cyclization by C-H activation” Handbook of Cyclization Reactions, wiley, published
Li, Z. et al. “Oxidation turns on the global regulator SarA in Staphylococcus aureus”
Li, Z. et al. “Small molecule inhibitor of global regulator MgrA tunes down the virulence of Staphylococcus aureus”