Li group published article on Organic & Biomolecular Chemistry about a study of Switching substitution groups on the in-tether chiral centre inﬂuences backbone peptides’ permeability and target binding aﬃnity

Home > Research Progress > Li group published article on Organic & Biomolecular Chemistry about a study of Switching substitution groups on the in-tether chiral centre inﬂuences backbone peptides’ permeability and target binding aﬃnity

Diﬀerent substitution groups on the in-tether chiral centre of chirality-induced helical peptides (CIH peptides) showed distinguishable eﬀects on the peptides’ cellular uptakes and binding aﬃnities with the estrogen receptor α(ER-α). This study proves that in-tether chiral centres are a valuable modiﬁcation site for constructing peptide ligands with preferable biophysical properties.

Link: http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02289H

12/12/2016 at 13:26

Research Progress

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Li Group

Key Laboratory of Chemical Genomics