Home > Research Progress > Li group published article on Synlett about a study of lipid–cell-penetrating-peptide conjugates as effective delivery systems

A lipid–cell-penetrating-peptide (CPP) conjugate was designed to deliver cargoes with poor cellular permeability, including peptides or small-molecule therapeutics, into cells. The lipid–CPP conjugate facilitated the cellular uptake of cargoes noncovalently through an ATP-dependent micropinocytosis mechanism. This delivery system is simple, efficient, has minimal cellular toxicity, and might be useful in a wide range of biological research.

Link: https://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588807.pdf