Home > Research Progress > Li group published article on Chemical Communication about a study of N terminal N-methylation modulates chiral centre induced helical (CIH) peptides’ biophysical properties

The N-methylation effects on CIH peptides’ biophysical properties were systematically studied. The N-methylation at the N terminal NH could help improve the peptides’ cellular uptakes with retained helical conformation. This Nmethylation strategy could also be applied to longer peptides to improve their stability and cellular uptakes.