We have developed a general peptide macrocyclization strategy that involves a facile and chemoselective methionine bis-alkylation/dealkylation process. This method provides a straightforward and easy approach to generate cyclic peptides with tolerances of all amino acids (including Cys), variable loop...
We have developed a facile N-terminus helix-nucleating strategy using an unnaturally tethered aspartic acid (TD strategy). Relatively weak nuclear translocation efficiency of TD PERM limits its further biological applications. A potent peptide inhibitor of estrogen receptor α (ER-α) with...
The eukaryotic-like Ser/Thr kinase Stk1 is crucial for virulence, cell wall biosynthesis, and drug susceptibility in methicillin-resistant Staphylococcus aureus (S. aureus) (MRSA). Importantly, MRSA lacking Stk1 become sensitive to β-lactam antibiotics, implying that Stk1 could be an alternative target...
Abstract The self-assembly of peptides into ordered nanostructures is important for understanding both peptide molecular interactions and nanotechnological applications. However, because of the complexity and various self-assembling pathways of peptide molecules, design of self-assembling helical peptides with high controllability...
Thanks to its tunable direct-bandgap, high charge-carrier mobility and unique in-plane anisotropic structure, black phosphorus (BP) has become a rising star of post-graphene two-dimensional (2D) nanomaterials. However, BP is unstable in the ambient conditions which largely limits its application....
Li group published article on Bioconjugate Chemistry about a study of Investigation of Cellular Uptakes of the In-Tether Chiral-CenterInduced Helical Pentapeptides We recently reported that a precisely positioned in-tether chiral center can modulate backbone peptides’ secondary structures, which provides an...
Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their therapeutic properties in targeting intracellular “undruggable” targets. Here, we describe the development of photo-induced intramolecular thiol–yne macrocyclization...
Li group published article on Nano Research about a study of A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field- effect transistors. 5-hydroxymethylcytosine (5-hmC) is an important epigenetic derivative of cytosine and quantitative...
Li group published article on Chembiochem. about a study of A Thioether-Stabilized d-Proline–l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability We report a β-hairpin dual stabilizing strategy: a d-proline-l-proline (d-Pro-l-Pro) dipeptide as the nucleating turn,...
Li group published article on Chemical Communications about a study of a proline-derived transannular N-cap for nucleation of short α-helical peptides We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via...
Li group published article on Chemical Communications about a study of An in-tether sulfilimine chiral center induces helicity in short peptides A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide’s secondary structure....
Li group published article on Cell Chemical Biology about a study of Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus The increasing threats of antibiotic resistance urge the need for developing new strategies against bacterial...
Li group published article on Angew Chem Int Ed about a study of crosslinked aspartic acids as helix-nucleating templates Described is a facile helix-nucleating template based on a tethered aspartic acid at the N-terminus . The...
Lanthanide chelate-encapsulated polystyrene nanoparticles for rapid and quantitative immunochromatographic assay of procalcitonin Procalcitonin (PCT) is a potentially specific early marker of bloodstream infection and sepsis. In this work, we report, for the first time, the development of a fluorescence-based...
Li group published article on Organic & Biomolecular Chemistry about a study of An in-tether sulfilimine chiral center induces ß turn conformation in short peptides A sulfilimine chiral center in the tether at i, i + 3 positions of short...