Abstract The self-assembly of peptides into ordered nanostructures is important for understanding both peptide molecular interactions and nanotechnological applications. However, because of the complexity and various self-assembling pathways of peptide molecules, design of self-assembling helical peptides with high controllability...
Thanks to its tunable direct-bandgap, high charge-carrier mobility and unique in-plane anisotropic structure, black phosphorus (BP) has become a rising star of post-graphene two-dimensional (2D) nanomaterials. However, BP is unstable in the ambient conditions which largely limits its application....
On October 22, 2016, we attended the Protein Folding Shape Alignment （PFSA）Meeting in Wuhan, students of our groups actively participated in the academic discussion and exchanged ideas.
A very nice trip in guilin, guangxi province, besides we had academic exchange with the students and teachers from Guangxi Normal University.
Prof. XU Naihan from Tsinghua University came to our group and gave us a report of cell death.
Kuan Hu ,Huacan Lin and Chengxiang Lei paticapated in the Fourth Hong Kong, Macao and Taiwan youth innovation business exchange camp last week and won the “Best Organization Award “! Congratulations! http://scbb.pkusz.edu.cn/index.php?m=content&c=index&a=show&catid=862&id=1064
We enjoyed in the sixth funny game and won the Team Runner-up!
Our lab member Yixiang Jiang won the championship of 6th “Freshman Cup” basketball game
Peptide stapling emerged as a versatile strategy to recapitulate the bioactive helical conformation of unstructured short peptides in water to improve their therapeutic properties in targeting intracellular “undruggable” targets. Here, we describe the development of photo-induced intramolecular thiol–yne macrocyclization...
The addition of a precisely positioned chiral center in the tether of a constrained peptide is reported, yielding two separable peptide diastereomers with significantly different helicity, as supported by circular dichroism (CD) and NMR spectroscopy. Single crystal X-ray diffraction analysis suggests that the...
Li group published article on Nano Research about a study of A simple and novel method for the quantitative detection of 5-hydroxymethylcytosine using carbon nanotube field- effect transistors. 5-hydroxymethylcytosine (5-hmC) is an important epigenetic derivative of cytosine and quantitative...
Li group published article on Chembiochem. about a study of A Thioether-Stabilized d-Proline–l-Proline-Induced β-Hairpin Peptide of Defensin Segment Increases Its Anti-Candida albicans Ability We report a β-hairpin dual stabilizing strategy: a d-proline-l-proline (d-Pro-l-Pro) dipeptide as the nucleating turn,...
Li group published article on Chemical Communications about a study of a proline-derived transannular N-cap for nucleation of short α-helical peptides We report herein a proline-derived transannular N-cap as a helix nucleating template in diverse bio-related peptide sequences via...
Li group published article on Chemical Communications about a study of An in-tether sulfilimine chiral center induces helicity in short peptides A precisely positioned sulfilimine chiral center in the tether of a stabilized peptide would determine the peptide’s secondary structure....
Li group published article on Cell Chemical Biology about a study of Structure-Based Identification of a Potent Inhibitor Targeting Stp1-Mediated Virulence Regulation in Staphylococcus aureus The increasing threats of antibiotic resistance urge the need for developing new strategies against bacterial...
