Publications
15.Tetramethyl Thiourea/Co2(CO)8- Catalyzed Pauson-Khand Reaction under Balloon Pressure of CO
Y. F. Tang, L. J. Deng, Y. D. Zhang, G. B. Dong, J. H. Chen*, Z. Yang*
Pauson−Khand type of conversion of enynes to bicyclic cyclopentenones employing the commercially available Co2(CO)8 and tetramethylthiourea (TMTU) as catalysts is described. This method allows a variety of enynes with diverse functional groups to be cyclized into cyclopentenones of interest.
*This publication was highlighted on http://www.organic-chemistry.org/Highlights/2005/12December.shtm
14.A Highly Efficient Synthesis of the FGH Ring of Micrandilactone A. Application of Thioureas as Ligands in the Co-catalyzed Pauson-Khand Reaction and Pd-Catalyzed Carbonylative Annulation
Y. F. Tang, Y. D. Zhang, M. J. Dai, T. P. Luo, L. J. Deng, J. H. Chen*, Z. Yang*
The functionalized FGH ring system of micrandilactone A was successfully constructed in high selectivity and good yields. The key reactions in our strategy are the Co−thiourea-catalyzed stereoselective, intramolecular Pauson−Khand reaction and Pd−thiourea-catalyzed stereoselective, intramolecular annulation.
13.Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as a Solvent
B. Liang, M. W. Huang, Z. J. You, Z. C. Xiong, K. Lu, R. Fathi, J. H. Chen*, Z. Yang*
The Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction to synthesize alkynyl ketones from terminal alkynes and aryl iodides was achieved by using water as a solvent. The reaction was carried out at room temperature under balloon pressure of CO with Et3N as a base. The developed method was successfully applied to the synthesis of flavones.
12.Linear C2-Symmetric Polycyclic Benzodithiophene: Efficient, Highly Diversified Approaches and the Optical Properties
C. H. Wang, R. Hu, S. Liang, J. H. Chen. Z. Yang*, J. Pei*
Tetrahedron Lett., 2005, 46, 8153.
Two facile approaches to two new series of the seven-rings fused benzodithiophene-based polycyclic aromatics are developed in good yields.
11.A Concise and Diversity-Oriented Strategy for the Synhteis of Benzofurans and Indoles via Ugi and Dields-Alder Reaction
K. Lu, T. P. Luo, Z. Xiang, Z. J. You, R. Fathi, J. H. Chen*, Z. Yang*
A one-pot synthesis of diverse benzofurans and indoles from readily available starting materials was achieved via the sequential Ugi four-component reaction, intramolecular Diels−Alder reaction, and oxidative aromatization.
