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Org. Lett. 2023, 25(13), 2264–2269
Shu-Min Lu, Chao Chen, Chang Liu, Rudong Liu, Jia-Hua Chen,* Zhongchao Zhang,* and Zhen Yang*
Regioselective synthesis of 5,6,7-trihydroxyl and 5,7,8-trihydroxyl flavones has been achieved via a transition-metal-catalyzed C–H oxidation as the key step using naturally enriched 5,7-dihydroxyl flavone. The developed chemistry was applied to the synthesis of the naturally occurring and biologically active flavonoids wogonin (2), oroxylin A (3), and their glycosylated derivatives (4and5) as...
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Angew. Chem. Int. Ed. 2023, 62(33)
Yuan-He Li, Su-Lei Zhang, Yong Lu, Bo Xiao, Tian-Yu Sun, Qian-Qian Xu, Jia-Hua Chen,* Zhen Yang*
A highly enantioselective catalytic system for exo-Diels–Alder reactions was developed based on the newly discovered bispyrrolidine diboronates (BPDBs). When activated various Lewis or Brønsted acids, BPDBs could catalyze highly stereoselective asymmetric exo-Diels–Alder reactions of monocarbonyl-based dienophiles. When 1,2-dicarbonyl-based dienophiles are used, the catalyst can sterically di...
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Tetrahedron Letters 2023, 117 (2023), 154361-154363
Zhiming Yan, Chunbo Zhao, Zhen Yang*, Jianxian Gong*
Zhiming Yan, Chunbo Zhao, Zhen Yang*, Jianxian Gong* Tetrahedron Letters 2023, 117 (2023), 154361-154363 We developed a concise, ten-step route to the 5/6 fused-spiro tricyclic framework (A/B/C rings)...
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SCIENTIA SINICA Chimica 2023, 53(3), 277-288
Zhongchao Zhang, Zhen Yang *
Zhongchao Zhang, Zhen Yang * SCIENTIA SINICA Chimica 2023, 53(3), 277-288 Contiguous all carbon quaternary stereocenters are common structural units in bioactive natural products with significant synt...
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National Science Review 2022, 9(11), nwac 176165.Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice
Hai-Xin Yu, Nan Zheng, Chi-Tai Yeh, Chien-Ming Lee, Qi Zhang, Wen-Lv Zheng, Qing Chang, Yuan-He Li, Yu-Jun Li, Gui-Zhen Wu∗, Jun-Min Quan∗, Lin-Qi Zhang∗, Yew-Min Tzeng∗ and Zhen Yang∗
Hai-Xin Yu, Nan Zheng, Chi-Tai Yeh, Chien-Ming Lee, Qi Zhang, Wen-Lv Zheng, Qing Chang, Yuan-He Li, Yu-Jun Li, Gui-Zhen Wu∗, Jun-Min Quan∗, Lin-Qi Zhang∗, Yew-Min Tzeng∗ and Zhen Yang∗ National S...
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Catalysts 2022, 12(3), 333
Anding Li, Nan Zheng, Kai Guo, Zhongchao Zhang and Zhen Yang*
Anding Li, Nan Zheng, Kai Guo, Zhongchao Zhang and Zhen Yang* Catalysts 2022, 12(3), 333 Electrochemical synthesis has been rapidly developing over the past few years. Here, we report a practical and ...
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J. Am. Chem. Soc. 2022, 144,(6), 2479–2483
Jun Huang,* Tingting Cao, Zhongchao Zhang, and Zhen Yang*
Jun Huang,* Tingting Cao, Zhongchao Zhang, and Zhen Yang* J. Am. Chem. Soc. 2022, 144,(6), 2479–2483 An enantioselective semisynthesis of (−)-bufospirostenin A is described. The key steps in the syn...
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Org. Lett. 2022, 24,(7), 1491–1495
Tingting Cao, Lei Zhu,* Jun Huang,* and Zhen Yang*
Tingting Cao, Lei Zhu,* Jun Huang,* and Zhen Yang* Org. Lett. 2022, 24,(7), 1491–1495 A sterically congested all-carbon quaternary center was installed for the first time via a Pd-catalyzed cascade d...
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Org. Lett. 2022, 24(21), 3786–3791
Lijie Zhang, Rongya Wang, Chao Wang, Bingyan Liu, Jinfeng Yang, Zhongchao Zhang, Jun Huang,*and Zhen Yang*
Lijie Zhang, Rongya Wang, Chao Wang, Bingyan Liu, Jinfeng Yang, Zhongchao Zhang, Jun Huang,*and Zhen Yang* Org. Lett. 2022, 24(21), 3786–3791 A spiro-oxepin isoxazoline skeleton was constructed via 1...
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Org. Lett. 2021, 23(21), 8465–8470
Jiangqun Cheng, Yuan-He Li, Jun Huang,* and Zhen Yang*
Jiangqun Cheng, Yuan-He Li, Jun Huang,* and Zhen Yang* Org. Lett. 2021, 23(21), 8465–8470 Diastereoselective syntheses of syn– and anti-vicinal dihalides were achieved via an aza-Belluš–Claisen re...